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hypoxia

MedGen UID:
66846
•Concept ID:
C0242184
•
Pathologic Function
Synonyms: Deficiencies, Oxygen; Deficiency, Oxygen; Hypoxia; Oxygen Deficiencies; Oxygen Deficiency
SNOMED CT: Hypoxia (389086002); Decreased oxygen supply (389086002); Hypoxic (389086002)

Definition

A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). [from NCI]

Professional guidelines

PubMed

Shock: aetiology, pathophysiology and management.
Blumlein D, Griffiths I
Br J Nurs 2022 Apr 21;31(8):422-428. doi: 10.12968/bjon.2022.31.8.422. PMID: 35439071
COVID-19 pandemic: from origins to outcomes. A comprehensive review of viral pathogenesis, clinical manifestations, diagnostic evaluation, and management.
Ochani R, Asad A, Yasmin F, Shaikh S, Khalid H, Batra S, Sohail MR, Mahmood SF, Ochani R, Hussham Arshad M, Kumar A, Surani S
Infez Med 2021 Mar 1;29(1):20-36. PMID: 33664170
Primary Dysmenorrhea: Assessment and Treatment.
Guimarães I, Póvoa AM
Rev Bras Ginecol Obstet 2020 Aug;42(8):501-507. Epub 2020 Jun 19 doi: 10.1055/s-0040-1712131. PMID: 32559803Free PMC Article

Recent clinical studies

Etiology

Hypoxia-Targeted Dose Painting in Radiotherapy.
Salem A
Semin Radiat Oncol 2023 Jul;33(3):298-306. doi: 10.1016/j.semradonc.2023.03.009. PMID: 37331784
Construction of a hypoxia-immune-related prognostic panel based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer.
Deng C, Deng G, Chu H, Chen S, Chen X, Li X, He Y, Sun C, Zhang C
Front Immunol 2023;14:1140328. Epub 2023 Apr 26 doi: 10.3389/fimmu.2023.1140328. PMID: 37180146Free PMC Article
Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial.
Bandyopadhyay A, Kumar P, Jafra A, Thakur H, Yaddanapudi LN, Jain K
Anesth Analg 2023 May 1;136(5):913-919. Epub 2023 Apr 14 doi: 10.1213/ANE.0000000000006171. PMID: 37058727
Hypoxia and brain aging: Neurodegeneration or neuroprotection?
Burtscher J, Mallet RT, Burtscher M, Millet GP
Ageing Res Rev 2021 Jul;68:101343. Epub 2021 Apr 15 doi: 10.1016/j.arr.2021.101343. PMID: 33862277
High altitude illness.
Hartman-Ksycińska A, Kluz-Zawadzka J, Lewandowski B
Przegl Epidemiol 2016;70(3):490-499. PMID: 27888818

Diagnosis

Construction of a hypoxia-immune-related prognostic panel based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer.
Deng C, Deng G, Chu H, Chen S, Chen X, Li X, He Y, Sun C, Zhang C
Front Immunol 2023;14:1140328. Epub 2023 Apr 26 doi: 10.3389/fimmu.2023.1140328. PMID: 37180146Free PMC Article
Neonatal electroencephalography recordings.
Yao D, Deng X, Wang M
Minerva Pediatr 2019 Jun;71(3):304-308. Epub 2016 Jul 21 doi: 10.23736/S0026-4946.16.04711-3. PMID: 27441493
Hypoxia and Placental Development.
Soares MJ, Iqbal K, Kozai K
Birth Defects Res 2017 Oct 16;109(17):1309-1329. doi: 10.1002/bdr2.1135. PMID: 29105383Free PMC Article
Biology of hypoxia.
Span PN, Bussink J
Semin Nucl Med 2015 Mar;45(2):101-9. doi: 10.1053/j.semnuclmed.2014.10.002. PMID: 25704383
Hypoxia-inducible factor-1 (HIF-1).
Ke Q, Costa M
Mol Pharmacol 2006 Nov;70(5):1469-80. Epub 2006 Aug 3 doi: 10.1124/mol.106.027029. PMID: 16887934

Therapy

Maternal fever in labor: etiologies, consequences, and clinical management.
Goetzl L
Am J Obstet Gynecol 2023 May;228(5S):S1274-S1282. Epub 2023 Mar 20 doi: 10.1016/j.ajog.2022.11.002. PMID: 36997396
Targeted Therapies in Pheochromocytoma and Paraganglioma.
Wang K, Crona J, Beuschlein F, Grossman AB, Pacak K, Nölting S
J Clin Endocrinol Metab 2022 Nov 23;107(11):2963-2972. doi: 10.1210/clinem/dgac471. PMID: 35973976Free PMC Article
Treatment of Diabetic Kidney Disease: Current and Future.
Yamazaki T, Mimura I, Tanaka T, Nangaku M
Diabetes Metab J 2021 Jan;45(1):11-26. Epub 2021 Jan 22 doi: 10.4093/dmj.2020.0217. PMID: 33508907Free PMC Article
Hyperbaric oxygen therapy and cancer--a review.
Moen I, Stuhr LE
Target Oncol 2012 Dec;7(4):233-42. Epub 2012 Oct 2 doi: 10.1007/s11523-012-0233-x. PMID: 23054400Free PMC Article
Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group.
Ann Intern Med 1980 Sep;93(3):391-8. doi: 10.7326/0003-4819-93-3-391. PMID: 6776858

Prognosis

Development and validation of a new scoring system for prognostic prediction of community-acquired pneumonia in older adults.
Shirata M, Ito I, Ishida T, Tachibana H, Tanabe N, Konishi S, Oi I, Hamao N, Nishioka K, Matsumoto H, Yasutomo Y, Kadowaki S, Ohnishi H, Tomioka H, Nishimura T, Hasegawa Y, Nakagawa A, Hirai T
Sci Rep 2021 Dec 13;11(1):23878. doi: 10.1038/s41598-021-03440-3. PMID: 34903833Free PMC Article
Hypoxia During One-Lung Ventilation-A Review and Update.
Campos JH, Feider A
J Cardiothorac Vasc Anesth 2018 Oct;32(5):2330-2338. Epub 2017 Dec 19 doi: 10.1053/j.jvca.2017.12.026. PMID: 29361458
Update on Anemia in ESRD and Earlier Stages of CKD: Core Curriculum 2018.
Fishbane S, Spinowitz B
Am J Kidney Dis 2018 Mar;71(3):423-435. Epub 2018 Jan 11 doi: 10.1053/j.ajkd.2017.09.026. PMID: 29336855
Hypoxia-related altitude illnesses.
Netzer N, Strohl K, Faulhaber M, Gatterer H, Burtscher M
J Travel Med 2013 Jul-Aug;20(4):247-55. Epub 2013 Mar 11 doi: 10.1111/jtm.12017. PMID: 23809076
Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy.
Kurinczuk JJ, White-Koning M, Badawi N
Early Hum Dev 2010 Jun;86(6):329-38. Epub 2010 Jun 16 doi: 10.1016/j.earlhumdev.2010.05.010. PMID: 20554402

Clinical prediction guides

Development and Verification of the Hypoxia- and Immune-Associated Prognostic Signature for Pancreatic Ductal Adenocarcinoma.
Chen D, Huang H, Zang L, Gao W, Zhu H, Yu X
Front Immunol 2021;12:728062. Epub 2021 Oct 6 doi: 10.3389/fimmu.2021.728062. PMID: 34691034Free PMC Article
Assessment of heart rate, acidosis, consciousness, oxygenation, and respiratory rate to predict noninvasive ventilation failure in hypoxemic patients.
Duan J, Han X, Bai L, Zhou L, Huang S
Intensive Care Med 2017 Feb;43(2):192-199. Epub 2016 Nov 3 doi: 10.1007/s00134-016-4601-3. PMID: 27812731
Clinical prediction models for bronchopulmonary dysplasia: a systematic review and external validation study.
Onland W, Debray TP, Laughon MM, Miedema M, Cools F, Askie LM, Asselin JM, Calvert SA, Courtney SE, Dani C, Durand DJ, Marlow N, Peacock JL, Pillow JJ, Soll RF, Thome UH, Truffert P, Schreiber MD, Van Reempts P, Vendettuoli V, Vento G, van Kaam AH, Moons KG, Offringa M
BMC Pediatr 2013 Dec 17;13:207. doi: 10.1186/1471-2431-13-207. PMID: 24345305Free PMC Article
Prognosis in severe brain injury.
Stevens RD, Sutter R
Crit Care Med 2013 Apr;41(4):1104-23. doi: 10.1097/CCM.0b013e318287ee79. PMID: 23528755
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.
Höckel M, Vaupel P
J Natl Cancer Inst 2001 Feb 21;93(4):266-76. doi: 10.1093/jnci/93.4.266. PMID: 11181773

Recent systematic reviews

Biomarkers of hypoxic-ischemic encephalopathy: a systematic review.
Caramelo I, Coelho M, Rosado M, Cardoso CMP, Dinis A, Duarte CB, Grãos M, Manadas B
World J Pediatr 2023 Jun;19(6):505-548. Epub 2023 Apr 21 doi: 10.1007/s12519-023-00698-7. PMID: 37084165Free PMC Article
Meconium-stained amniotic fluid.
Gallo DM, Romero R, Bosco M, Gotsch F, Jaiman S, Jung E, Suksai M, Ramón Y Cajal CL, Yoon BH, Chaiworapongsa T
Am J Obstet Gynecol 2023 May;228(5S):S1158-S1178. Epub 2023 Apr 1 doi: 10.1016/j.ajog.2022.11.1283. PMID: 37012128Free PMC Article
Advances in Neonatal Acute Kidney Injury.
Starr MC, Charlton JR, Guillet R, Reidy K, Tipple TE, Jetton JG, Kent AL, Abitbol CL, Ambalavanan N, Mhanna MJ, Askenazi DJ, Selewski DT, Harer MW; Neonatal Kidney Collaborative Board
Pediatrics 2021 Nov;148(5) Epub 2021 Oct 1 doi: 10.1542/peds.2021-051220. PMID: 34599008
Etiology and Management of Acute Metabolic Acidosis: An Update.
Matyukhin I, Patschan S, Ritter O, Patschan D
Kidney Blood Press Res 2020;45(4):523-531. Epub 2020 Jul 14 doi: 10.1159/000507813. PMID: 32663831
Cooling for newborns with hypoxic ischaemic encephalopathy.
Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD003311. doi: 10.1002/14651858.CD003311.pub3. PMID: 23440789Free PMC Article

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